期刊
MULTIPLE SCLEROSIS
卷 12, 期 2, 页码 133-142出版社
HODDER ARNOLD, HODDER HEADLINE PLC
DOI: 10.1191/135248506ms1264oa
关键词
acquired immunodeficiency syndrome; demyelination; HIV; leukoencephalopathy; multiple sclerosis; polyomavirus; progressive multifocal
Many human neurological diseases involve demyelination of the central and/or peripheral nervous systems. These include the hereditary leukodystrophies - which have a genetic basis; multiple sclerosis ( MS) - where the underlying cause of demyelination remains unknown; and progressive multifocal leukoencephalopathy (PML) - where the etiology is well-established as being viral. The human neurotropic polyomavirus - JC virus ( JCV) - is the etiologic agent of PML, a fatal demyelinating disease of the central nervous system that occurs mainly in immunosuppressed patients, especially those with HIV/AIDS. JCV belongs to the polyomavirus family of tumor viruses that are characterized by non-enveloped icosahedral capsids containing small, circular, double-stranded DNA genomes. Serological studies have shown that JCV is widespread throughout the human population, but infections are usually restricted by the immune system, particularly cell-mediated immunity, causing the virus to enter a latent phase. An important corollary of this is that situations of severe immunosuppression may permit JCV to replicate and are thus a risk factor for PML.
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