期刊
SCHIZOPHRENIA BULLETIN
卷 32, 期 2, 页码 274-278出版社
OXFORD UNIV PRESS
DOI: 10.1093/schbul/sbi064
关键词
schizophrenia; deficit syndrome; factor analysis; negative symptoms; avolition; emotion
类别
资金
- NIMH NIH HHS [K24 MH001699-01A2, K24 MH001699, 1K24MH01699, 1P30MH59342] Funding Source: Medline
Deficit schizophrenia (DS) is considered a distinct subtype within the diagnosis of schizophrenia. While the common assumption is that DS represents a single, cohesive domain of psychopathology, the factorial structure of DS has not been investigated. We assessed 52 individuals with DSM-IV diagnoses of schizophrenia with DS. A principal component analysis (PCA) was conducted on the symptoms of the Schedule for the Deficit Syndrome. The PCA resulted in 2 distinct factors explaining 73.8% of the variance. Factor 1 (avolition) is made up of symptoms of curbing of interests, diminished sense of purpose, and diminished social drive. Factor 2 (emotional expression) is made up of symptoms of restricted affect, diminished emotional range, and poverty of speech. The results indicate that DS is best characterized by these 2 factors. The great majority of participants (86%) displayed DS symptoms from both factors. On average, participants had 4.19 (S.D. = 1.39) symptoms that were primary, enduring, and at least moderate in severity. The mean severity of symptoms was 2.25 (S.D. = 1.06). We discuss possible links between the obtained factors and putative neurobiological mechanisms, as well as directions for future research.
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