期刊
BIOMETRICAL JOURNAL
卷 48, 期 2, 页码 271-285出版社
WILEY
DOI: 10.1002/bimj.200510175
关键词
confidence interval; hypothesis testing; between-trial variance; normal response; binary response
In a random-effects meta-analysis, a new confidence interval for the heterogeneity parameter is proposed. With this interval, the amount of heterogeneity in a meta-analysis can be assessed so that it can be judged whether the pooling of the estimates is meaningful. Through suitable corrections of the lower bound, based on the treatment effect measure of interest, the resulting interval yields satisfactory results with respect to the predefined confidence coefficient. Lower and upper bound of the interval can be used for one-sided hypothesis testing on the amount of the underlying between-trial variability.
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