期刊
NATURE BIOTECHNOLOGY
卷 24, 期 4, 页码 435-436出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1198
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资金
- NCI NIH HHS [CA79553] Funding Source: Medline
- NCRR NIH HHS [U42 RR018877, R01 RR013438] Funding Source: Medline
- NIDDK NIH HHS [P30 DK040561, P30 DK040561-11, R01 DK064207-01, R01DK64207, R01 DK064207] Funding Source: Medline
- NIH HHS [T32 OD011126] Funding Source: Medline
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
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