期刊
PEPTIDES
卷 27, 期 4, 页码 812-819出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2005.09.009
关键词
neuropeptide; endocrine; osmoregulation; seawater transfer; CGRP receptor; gill
Osmoregulation is a major challenge in aquatic animals involving a complex endocrine control. We investigated the potential role of calcitonin gene-related peptide (CGRP, a neuromediator in mammals) in the endocrine control of the gill in a teleost, the eel. Transfer from freshwater to seawater induced an hyperosmolality and a concomitant large increase in plasma CGRP levels. Specific CGRP binding sites were characterized in the gill and their number was up-regulated after seawater transfer. This study suggests that the endocrine control of gill function during osmoregulation may represent an ancient role of CGRP in vertebrates. (c) 2005 Elsevier Inc. All rights reserved.
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