期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 21, 期 2, 页码 188-192出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.1002/jca.20085
关键词
arbekacin; habekacin; rifampin; sultamicillin; teicoplanin quinipristin-dalfopristin; vancomycin resistance; Staphylococcus aureus; hetero-VISA; time-kill assay
This study was undertaken to evaluate the in vitro activities of arbekacin-based combination regimens against vancomycin hetero-intermediate Staphylococcus aureus (hetero-VISA). Combinations of arbekacin with vancomycin, rifampin, ampicillin-sulbactam, teicoplanin, or quinipristin-dalfopristin against seven hetero-VISA strains and two methicillin-resistant S. aureus strains were evaluated by the time-kill assay. The combinations of arbekacin with vancomycin, teicoplanin, or ampicillin-sulbactam showed the synergistic interaction against hetero-VISA strains. Data suggest that these arbekacin-based combination regimens may be useful candidates for treatment options of hetero-VISA infections.
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