期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 17, 期 2, 页码 233-243出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2006.02.007
关键词
fertilization mechanism; sperm-egg interaction; intracellular calcium; sperm factor; egg activation
It was discovered about 30 years ago that a dramatic increase in intracellular calcium ion concentration ([Ca2+](i)) occurs at fertilization and that this increase acts as the pivotal signal for egg activation. Later, the Ca2+ signal at fertilization turned out to be ubiquitous among animal species. Extensive advance has been brought during these 30 years in research on spatiotemporal aspects and signaling mechanisms of the [Ca2+](i) increase, sperm factors that induce the Ca2+ response, and cell cycle resumption caused by the [Ca2+](i) rise. I provide a historical account of these advances in mammals, sea urchins, and a few other models. (c) 2006 Elsevier Ltd. All rights reserved.
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