期刊
JOURNAL OF INFECTIOUS DISEASES
卷 193, 期 7, 页码 917-926出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/500561
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Human herpesvirus (HHV)-7 is a ubiquitous virus that infects > 90% of adults. We show that HHV-7 impairs beta(2)-microglobulin and human leukocyte antigen (HLA) class I and II expression in lymphoid cells in vitro. Accordingly, infected cells were more sensitive to peripheral blood natural cytotoxic activity than were uninfected cells. Analysis of beta(2)-microglobulin and HLA expression in biopsy specimens from human submandibular glands confirmed the ability of HHV-7 to modulate the expression of these antigens in vivo. We demonstrate that the down-modulation of HLA by HHV-7 is linked to viral replication and is not merely a consequence of the interaction of virions with the cell surface. Infected cells can therefore efficiently escape host immune pressure, which might explain the persistence of HHV-7-positive cells in several kinds of tumors and chronic infectious diseases.
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