期刊
TRENDS IN GENETICS
卷 22, 期 4, 页码 193-196出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2006.02.001
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In this article, we show that introns; harboring translocation breakpoints in tumors are significantly longer than non-translocated introns; of the same genes but are not enriched significantly in sequence elements potentially involved in chromosomal rearrangements. Our findings provide evidence that double-strand breaks, the type of DNA damage that leads to translocations; in tumors, are created at random points in the genome, and that sequence elements do not have a widespread role in the localization of these breaks.
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