期刊
MICROBIAL PATHOGENESIS
卷 40, 期 4, 页码 171-176出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2005.12.006
关键词
cord factor; macrophage scavenger receptor; tumor necrosis factor alpha; macrophage inflammatory protein-1 alpha; alveolar macrophage; Kupffer cell
We aimed to reveal the regulatory function of macrophage scavenger receptor-A (MSR-A) in proinflammatory cytokine production by macrophages stimulated with rnycobacterial cord factor (CF). By the culture with CF, MSR-A (+/+) alveolar macrophages and Kupffer cells produced TNF-alpha/MIP-1 alpha in a time- and dose-dependent manner However, the amounts of cytokines produced by them were much less compared to those produced by MSR-A (-/-) macrophages. Consistent with this, treatment of MSR-A (+/+) macrophages with anti-MSR-A antibody increased TNF-alpha. production. Binding of CF to MSR-A was demonstrated by measuring the binding affinity. These. results indicate that CF binds MSR-A, and MSR-A down-regulates TNF-alpha/MIP-1 alpha. production by activated macrophages, suggesting the role of this receptor in suppression of excessive inflammatory responses during mycobacterial infection. (c) 2006 Elsevier Ltd. All rights reserved.
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