期刊
NATURE BIOTECHNOLOGY
卷 24, 期 4, 页码 437-438出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt1199
关键词
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Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.
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