期刊
CRITICAL REVIEWS IN MICROBIOLOGY
卷 32, 期 2, 页码 69-75出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10408410600709768
关键词
IdeR regulon; virulence; iron acquisition; antibiotic resistance; siderophore
类别
In mycobacteria, iron dependent transcription regulator ( IdeR) regulates transcription of genes in response to iron levels. The IdeR regulated genes have been investigated mostly in M. tuberculosis, M. smegmatis, and in few of the other related species. Recent advances in crystal structure solution and computational as well as experimental identification of IdeR targets has provided insight into IdeR structure and function. Here in this review we take stock of current state of knowledge on IdeR and its targets to understand the underlying design of the IdeR regulon and its role in mycobacterial physiology.
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