期刊
CURRENT OPINION IN PEDIATRICS
卷 18, 期 2, 页码 101-106出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.mop.0000193300.25141.c5
关键词
central venous catheter; fluconazole; neonate; probiotics; sepsis
类别
Purpose of review Infants hospitalized in the neonatal intensive care unit, particularly preterm infants, have very high rates of nosocomial sepsis (also referred to as late onset sepsis or healthcare-associated sepsis). Today's preventive strategies for nosocomial sepsis focus on augmenting the immunologic and functional immaturities of premature infants and ameliorating the risks of extrinsic factors by the use of prophylactic antibiotics and best clinical practices. Recent findings Topical emollients improved neonatal skin condition, but were associated with an increased risk of nosecomial bacterial sepsis and coagulase negative staphylococcal infections, and thus should not be used in extremely-lowbirth-weight infants. Single-center studies have shown that probiotics containing anaerobic bacteria may reduce the rate of necrotizing enterocolitis, the severity of necrotizing enterocolitis, and/or bacterial sepsis. Single-center studies have shown that prophylactic fluconazole reduces the rates of invasive candidiasis and/or colonization of extremely-lowbirth-weight infants, Quality improvement projects to improve adherence to appropriate hand hygiene and best practices for central venous catheter insertion and maintenance can reduce rates of nosocomial sepsis. Summary The safety and efficacy of probiotics and prophylactic fluconazole require large multicenter trials. Quality improvement initiatives, however, can be performed now and can reduce the rates of nosocomial sepsis in the neonatal intensive care unit.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据