期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 7, 页码 1965-1968出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.12.068
关键词
calpain inhibitors; peptidomimetic; urea-based calpain inhibitors; peptidyl aldehyde inhibitors
资金
- NCI NIH HHS [R21CA104982] Funding Source: Medline
A series of peptide aldehyde derivatives in which the P-2 chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of mu-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for mu-calpain over cathepsin B. (C) 2006 Elsevier Ltd. All rights reserved.
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