期刊
MAGNETIC RESONANCE IMAGING
卷 24, 期 3, 页码 273-278出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2005.12.004
关键词
oncology; proton diffusion; sodium; magnetic resonance; tumor; chemotherapy
资金
- NCI NIH HHS [R24 CA083099, R21 CA119177-01, P01CA85878, R21 CA119177, P50CA93990, R24CA83099, P50 CA093990, P01 CA085878] Funding Source: Medline
- NIGMS NIH HHS [T32 GM145304] Funding Source: Medline
The ability to quantitate early effects of tumor therapeutic response using noninvasive imaging would have a major impact in clinical oncology. One area of active research interest is the ability to use MR techniques to detect subtle changes in tumor cellular density. In this study, sodium and proton diffusion MRI were compared for their ability to detect early cellular changes in tumors treated with a cytotoxic chemotherapy. Subcutaneous 9L gliosarcomas were treated with a single dose of 1,3-bis(2-chloroethyl)-1-nitrosourea. Both sodium and diffusion imaging modalities were able to detect changes in tumor cellularity as early as 2 days after treatment, which continued to evolve as increased signal intensities reached a maximum similar to 8 days posttreatment. Early changes in tumor sodium and apparent diffusion coefficient values were predictive of subsequent tumor shrinkage, which occurred similar to 10 days later. Overall, therapeutical induced changes in sodium and diffusion values were found to have similar dynamic and spatial changes. These findings suggest that these imaging modalities detected similar early cellular changes after treatment. The results of this study support the continued clinical testing of diffusion MRI for evaluation of early tumor treatment response and demonstrate the complementary insights of sodium MRI for oncology applications. (C) 2006 Elsevier Inc. All rights reserved.
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