期刊
MATRIX BIOLOGY
卷 25, 期 3, 页码 185-188出版社
ELSEVIER
DOI: 10.1016/j.matbio.2005.11.004
关键词
collagen XVII; immunohistochemistry; human brain; neuron; migration; in situ hybridisation
Type XVII collagen (collagen XVII) is a component of hemidesmosomes, which connect epithelia] cells to the underlying basement membrane. Previously, an association has been suggested between neurological disorders and the skin disease bullous pemphigoid, where autoimmunity is directed against collagen XVII. Furthermore, the lack of alpha 6 integrin, a ligand of collagen XVII, has been implicated in defects of cortical organization in the mouse brain. In this study, we demonstrate for the first time the presence of collagen XVII in neurons of the human brain by in situ hybridisation, immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). We propose that collagen XVII may be involved in the pathogenesis of various disorders affecting neuronal migration or synaptic plasticity. (c) 2005 Elsevier B.V./International Society of Matrix Biology. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据