期刊
MOLECULAR BIOLOGY OF THE CELL
卷 17, 期 4, 页码 1495-1502出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E05-10-0908
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资金
- NIGMS NIH HHS [R01 GM052932, GM 52932] Funding Source: Medline
Regulated exocytosis is thought to occur either by full fusion, where the secretory vesicle fuses with the plasma membrane (PM) via a fusion pore that then dilates until the secretory vesicle collapses into the PM; or by kiss-and-run, where the fusion pore does not dilate and instead rapidly reseals such that the secretory vesicle is retrieved almost fully intact. Here, we describe growing evidence for a third form of exocytosis, dubbed kiss-and-coat, which is characteristic of a broad variety of cell types that undergo regulated exocytosis. Kiss-and-coat exocytosis entails prolonged maintenance of a dilated fusion pore and assembly of actin filament (F-actin) coats around the exocytosing secretory vesicles followed by direct retrieval of some fraction of the emptied vesicle membrane. We propose that assembly of the actin coats results from the union of the secretory vesicle membrane and PM and that this compartment mixing represents a general mechanism for generating local signals via directed membrane fusion.
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