Voriconazole therapeutic drug monitoring

We report on 28 patients who underwent voriconazole monitoring because of disease progression or toxicity. A relationship (P < 0.025) between disease progression and drug concentration was detected. Favorable responses were observed in 10/10 patients with concentrations above 2.05 mu g/ml, while disease progressed in 44% (n = 18) of patients with concentrations below 2.05 mu g/ml.