期刊
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
卷 20, 期 2, 页码 112-117出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wad.0000213815.20177.19
关键词
imaging; epidemiology; progression
资金
- NIA NIH HHS [R01 AG26158] Funding Source: Medline
Epidemiologic evidence suggests that individuals with higher IQ, education, occupational attainment, or participation in leisure activities have a reduced risk of developing Alzheimer disease (AD). The concept of cognitive reserve (CR) posits that individual differences in how tasks are processed provide differential reserve against brain pathology or age-related changes. This may take 2 forms. In neural reserve, preexisting brain networks that are more efficient or have greater capacity may be less susceptible to disruption. In neural compensation, alternate networks may compensate for pathology's disruption of preexisting networks. Imaging studies have begun to identify the neural substrate of CR. Because CR may modulate the clinical expression. of AD pathology, it is an important consideration in studies of preclinical AD and treatment studies. There is also the possibility that directly enhancing CR may help forestall the diagnosis of AD.
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