期刊
BIOMEDICAL RESEARCH-TOKYO
卷 27, 期 2, 页码 89-92出版社
BIOMEDICAL RESEARCH PRESS LTD
DOI: 10.2220/biomedres.27.89
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The active form of vitamin D-3, 1 alpha,25-dihydroxyvitamin D-3 (DVD), is a potent inducer of cell differentiation and inhibits proliferation of cells such as human promyelocytic leukemia HL-60 cells. In the present study, we examined the effects of DVD on the expression of exportin-1 and exportin-1, which play essential roles in the transport of mRNA and tRNA, respectively. The results of reverse transcription-polymerase chain reaction and quantitative real-time polymerase chain reaction indicated that DVD down-regulated the gene expression of these exportins. Western blotting revealed the decreased production of these proteins in DVD-treated cells. Thus, the present findings of decreased expression of exportin-1 and exportin-t induced by DVD can be correlated to inhibition of the proliferation of HL-60 cells.
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