期刊
CURRENT OPINION IN IMMUNOLOGY
卷 18, 期 2, 页码 152-157出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2006.01.012
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- NIAID NIH HHS [5-R01-AI053545, R01-AI050867] Funding Source: Medline
A combination of various post-translational modifications regulates the formation of signaling networks in both the nucleus and the cytosol. Of these, lysine methylation provides a relatively stable marker on histories and contributes to the formation of a distinct pattern of histone-dependent gene regulation ('transcriptional memory'). Thus far, lysine methylation was considered to be nucleus specific; however, recent findings indicate that lysine methylation contributes to receptor-mediated signal transduction in the cytosol.
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