4.7 Article

Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients

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ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 50, 期 4, 页码 1599-1602

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AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.50.4.1599-1602.2006

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We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29 +/- 28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n = 13; anemia, n = 7; gastrointestinal, n = 12; peripheral neuropathy, n = 1; serotonin syndrome, n = 1), such that a systematic monitoring protocol was developed.

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