期刊
JOURNAL OF DENTAL RESEARCH
卷 85, 期 4, 页码 318-323出版社
INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R
DOI: 10.1177/154405910608500407
关键词
microbiology; tongue; subgingival; health; early periodontitis
资金
- NCRR NIH HHS [RR-00533, M01 RR001032, RR-01032, M01 RR000533] Funding Source: Medline
- NIDCR NIH HHS [DE-11443, R01 DE011443, R01 DE009513, DE-09513] Funding Source: Medline
Periodontal infections have a microbial etiology. Association of species with early disease would be useful in determining which microbes initiate periodontitis. We hypothesized that the microbiota of subgingival and tongue samples would differ between early periodontitis and health. A cross-sectional evaluation of 141 healthy and early periodontitis adults was performed with the use of oligonucleotide probes and PCR. Most species differed in associations with sample sites; most subgingival species were associated with subgingival samples. Few species were detected more frequently in early periodontitis by DNA probes. Porphyromonas gingivalis and Tannerella forsythia ( Tannerella forsythensis) were associated with early periodontitis by direct PCR. In conclusion, the microbiota of tongue samples was less sensitive than that of subgingival samples in detecting periodontal species, and there was overlap in species detected in health and early periodontitis. Detection of periodontal pathogens in early periodontitis suggests an etiology similar to that of more advanced disease.
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