期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 55, 期 4, 页码 251-258出版社
WILEY
DOI: 10.1111/j.1600-0897.2005.00357.x
关键词
controlled ovarian hyperstimulation; follicle-stimulating hormone; 5,10-methylene tetrahydrofolate reductase; ovarian reserve; ovarian responsiveness
Problem The common 677C > T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene is less prevalent in mothers of spontaneously conceived dichorionic twins than in those with singleton pregnancies. (Hasbargen U, Lohse P, Thaler CJ: Hum Reprod 2000; 15:2659-2662). As polyovulation is a pre-requisite for dichorionic pregnancies, we investigated whether the T allele is associated with reduced ovarian responsiveness to follicle-stimulating hormone (FSH). Materials and methods We studied 105 infertility patients undergoing a total of 269 A.R.T cycles stimulated with recombinant (r)-FSH. The MTHFR 677C > T genotype was analyzed by digestion of polymerase chain reaction-amplified DNA fragments. Results Homozygous 677C patients older than 35, required significantly (P < 0.02) less r-FSH and produced significantly more oocytes (P < 0.04) and higher maximal serum estradiol concentrations (P < 0.002) than heterozygous or homozygous carriers of the 677T allele. Conclusion Our results suggest that, in patients of advanced reproductive age, the MTHFR 677C > T mutation affects ovarian responsiveness.
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