期刊
MICROELECTRONIC ENGINEERING
卷 83, 期 4-9, 页码 1598-1601出版社
ELSEVIER
DOI: 10.1016/j.mee.2006.01.113
关键词
porous silicon; controlled drug delivery; doxorubicin; post-surgical chemotherapy
One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 mu m average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits. (c) 2006 Published by Elsevier B.V.
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