期刊
FASEB JOURNAL
卷 20, 期 6, 页码 601-605出版社
WILEY
DOI: 10.1096/fj.05-5401hyp
关键词
apoptosis; caspases; eosinophils; inflammation; neutrophils; non-apoptotic cell death; Siglecs
The regulation of cell death is a key element in building up and maintaining both innate and adaptive immunity. A critical role in this process plays the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor family of death receptors. Recent work suggests that sialic acid binding immunoglobulin (Ig) -like lectins (Siglecs) are also empowered to transmit death signals, at least into myeloid cells. Strikingly, death induction by Siglecs is enhanced when cells are exposed to proinflammatory survival cytokines. Based on these recent insights, we hypothesize that at least some members of the Siglec family regulate immune responses via the activation of caspase-dependent and caspase-independent cell death pathways. von Gunten, S., Simon, H.-U. Sialic acid binding immunoglobulinlike lectins ( Siglecs) may regulate innate immune responses by modulating the life span of granulocytes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据