期刊
THERMOCHIMICA ACTA
卷 443, 期 1, 页码 132-135出版社
ELSEVIER
DOI: 10.1016/j.tca.2005.12.025
关键词
microcalorimetry; complex stability constants; thermodynamic parameters; inclusion complexation; calix[n]arenesulfonates
Calorimetric titration and NMR experiments in aqueous phosphate buffer (pH 7.2) at 298.15 K have been done to determine the binding mode, complex stability constants and thermodynamics (Delta G degrees, Delta H degrees, and T Delta S degrees) for 1:1 inclusion complexation of water-soluble calix[n]arenesulfonates (CnAS, n = 4 and 6) and thiacalix[4]arene tetrasulfonate (TCAS) with acethylcholine, carnitine, betaine and benzyltrimethyl ammonium ion. The results show the inclusion complexations are driven by enthalpy (Delta H degrees < 0), accompanied by negative entropic changes (Delta S degrees < 0). The binding affinities (C4AS > C6AS > TCAS) are discussed from the viewpoint of CH-pi/pi-pi interactions, electrostatic interactions and size/shape-fit relationship between host and guest. (c) 2006 Elsevier B.V. All rights reserved.
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