期刊
TRENDS IN IMMUNOLOGY
卷 27, 期 4, 页码 161-164出版社
ELSEVIER SCI LTD
DOI: 10.1016/J.IT.2006.02.002
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资金
- Intramural NIH HHS Funding Source: Medline
An intimate but deadly encounter between natural killer (NK) cells and transformed cells results in the delivery of cytotoxic molecules into tumor cells. New evidence reveals another intimate association, this time between NK cells and regulatory T cells, but this encounter opposes NK-cell tumoricidal activity. Through a contact-dependent mechanism involving transforming growth factor-beta, regulatory T cells provide an escape mechanism from INK-cell-mediated tumor surveillance.
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