期刊
EXPERT REVIEW OF ANTICANCER THERAPY
卷 6, 期 4, 页码 515-530出版社
TAYLOR & FRANCIS LTD
DOI: 10.1586/14737140.6.4.515
关键词
CDK4; CDKN2A; cyclin D1; DNA aberrations; lung cancer; retinoblastoma
类别
The retinoblastoma (RB)-Cyclin (CCN)D1-p16 cell cycle pathway has a crucial role in lung tumorigenesis. Impairment of the RB pathway has been shown to occur in almost all lung tumors. A deregulation at any level of this core RB pathway seems to make cells insensitive to the mitogenic signaling that is required for cell cycle progression. To date, almost all participants in this pathway have been shown to be altered to a various degree in lung tumors. Some of the alterations are mutually exclusive, Including RB and p 16(INK4A). In small cell lung cancer, the RB tumor suppressor gene is inactivated in almost 90% of the tumors, whereas in non-small cell lung cancer, the cyclin-dependent kinase (CDK)4 inhibitor p16(INK4A) is inactivated in 40-60% of the tumors. Many mechanisms may be responsible for activafing the RB-Cyclin DI pathway, including activating (CDK4) and inactivating mutations (p16(INK4A)), deletions (RB and p16(INK4A)), amplifications (CCND1 and CDK4), silencing methylation (p16(INK4A) and RB), and hyper-phosphorylation (RB). As some of these alterations, such as p16(INK4A) methylation, can also be detected in bronchial lavage and serum, they could potentially serve as useful markers for the early detection of lung cancer. This review summarizes recent experiments describing the variable roles of keyplayer molecules of the RB pathway and different mechanisms by which the RB pathway can be altered in lung cancer.
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