期刊
INFECTION AND IMMUNITY
卷 74, 期 4, 页码 2446-2448出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.74.4.2446-2448.2006
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资金
- NIAID NIH HHS [T32 AI007362, 5T32AI07362, R01 AI23302, R01 AI023302] Funding Source: Medline
Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thiredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P carinii burdens after CD4(+) T-cell depletion and challenge with P. carinii.
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