期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 173, 期 1-2, 页码 180-187出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.11.018
关键词
leukocytes; lymphocytes; schizophrenia; real time PCR; expression profile
The expression of dopamine receptors was examined in purified human neutrophils, irionocytes, B cells, natural killer cells and CD4(+)- and CD8(+)-T lymphocytes by RT-PCR. In healthy subjects, D1 and D2 receptors were not expressed in leukocytes. Real Time PCR for doparnine receptors D3 and D4 disclosed that D3 receptors are expressed in T cells and natural killer cells and D4 receptors in CD4(+)-T cells. The comparison of schizophrenic patients with sex- and age-matched controls revealed a significantly higher expression of D3 receptor mRNA in T cells of schizophrenic patients, whereas D4 receptor mRNA in CD4(+)-T cells was downregulated. (c) 2005 Elsevier B.V. All rights reserved.
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