期刊
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
卷 54, 期 4, 页码 467-472出版社
SAGE PUBLICATIONS LTD
DOI: 10.1369/jhc.5A6755.2005
关键词
2P-domain potassium channel; carotid body; membrane potential; immunocytochemistry; rat
类别
TREK-1 is one of the important potassium channels for regulating membrane excitability. To examine the distribution of TREK-1 in the rat carotid body, we performed RTPCR for mRNA expression and in situ hybridization and immunohistochemistry for tissue distribution of TREK-1. RT-PCR detected mRNA expression of TREK-1 in the carotid body. Furthermore, in situ hybridization revealed the localization of TREK-1 mRNA in the glomus cells. TREK-1 immunoreactivity was mainly distributed in the glomus cells and nerve fibers in the carotid body. TREK-1 may modulate potassium current of glomus cells and/or afferent nerve endings in the rat carotid body.
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