期刊
NATURE IMMUNOLOGY
卷 7, 期 4, 页码 382-391出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1314
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资金
- NIAID NIH HHS [R01 AI033062, R37 AI033062-09A1, R37 AI033062, R01 AI042254-10, 5T32 AI07529, 5R37 R01 AI33062, R01 AI042254] Funding Source: Medline
Ikaros is expressed in early hematopoietic progenitors and is required for lymphoid differentiation. In the absence of Ikaros, there is a lack of markers defining fate restriction along lympho-myeloid pathways, but it is unclear whether formation of specific progenitors or expression of their markers is affected. Here we use a reporter based on Ikaros regulatory elements to separate early progenitors in wild-type and Ikaros-null mice. We found previously undetected Ikaros-null lympho-myeloid progenitors lacking the receptor tyrosine kinase Flt3 that were capable of myeloid but not lymphoid differentiation. In contrast, lack of Ikaros in the common myeloid progenitor resulted in increased formation of erythro-megakaryocytes at the expense of myeloid progenitors. Using this approach, we identify previously unknown pivotal functions for Ikaros in distinct fate 'decisions' in the early hematopoietic hierarchy.
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