期刊
BIOLOGY OF REPRODUCTION
卷 74, 期 4, 页码 684-690出版社
OXFORD UNIV PRESS INC
DOI: 10.1095/biolreprod.105.049312
关键词
gamete biology; manchette; molecular motor; nuclear pore; RAN; sperm; spermatid; spermatogenesis; testis
资金
- NIGMS NIH HHS [GM60628] Funding Source: Medline
KIFC1 is a C-terminal kinesin motor associated with the nuclear membrane and acrosome in round and elongating spermatids. This location in developing spermatids is consistent with possible roles in acrosome elongation and manchette motility or both. Here we describe the association of the KIFC1 motor with a complex containing the nucleoporin NUP62. Formation of this complex is developmentally regulated, being absent before puberty and appearing only after nuclear elongation has begun. in addition, the integrity of this complex is dependent on GTP hydrolysis and the GTP state of the small GTPase RAN. Concomitant with the association of this motor with the NUP62-containing complex is an apparent reorganization of the nuclear pore with loss of NUP62 from larger complexes containing other nucleoporins. The association of KIFC1 with a component of the nuclear membrane is more consistent with a role for this motor in acrosome/manchette transport along the nuclear membrane than for a role for this motor in transport of vesicles along the outer face of the manchette.
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