期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 49, 期 7, 页码 2253-2261出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm051219x
关键词
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A series of 1,3,4-benzotritzepine-based CCK2 antagonists have been devised by consideration of the structural features that govern CCK receptor affinity and the receptor subtype selectivity of 1,4-benzodiazepine-based CCK2 antagonists. In contrast to the latter compounds, these novel 1.3.4-benzotriazepines are achiral, yet they display similar affinity for CCK2 receptors to the earlier molecules and are highly selective over CCK1 receptors.
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