A kind of novel three-dimensional crosslinked networks based oil the self-assemly of alpha-CDs with thiolated four-arm PEG was prepared by thiol-disulfide interchange reaction using a three-step oxidation. The supramolecular structure of the resulting hydrogels was characterized vi FTIR, H-1 NMR, XRD, DSC and TGA measurements. The results demonstrated that the channel-type crystalline structure of inclusion complexes is still maintained after the multi-step oxidation. According to the swelling and degradation tests, the swelling behaviors and degradation properties can be readily regulated by tuning the feed compositions of a-CDs and PEG-thiolated prepolymer. Furthermore, the threading alpha-CDs clearly protects disulfide bonds from ail attack of a reduced form of glutathione as a result of prolonging the degradation time of the hydrogels in water.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据