期刊
JOURNAL OF CONTROLLED RELEASE
卷 111, 期 3, 页码 316-324出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2005.12.025
关键词
nanogels; self-assembly; drug; cyclodextrins; inclusion complex
We show here, for the first time, that two neutral polymers may completely associate together in water to spontaneously form supramolecular nanoassemblies (nanogels) of spherical shape. The cohesion of these stable structures of about 200 nm is based upon a lock and key mechanism: inclusion complexes are formed between the hydrophobic alkyl chains grafted on a polysaccharide (dextran) and the molecular cavities contained in a poly-cyclodextrin polymer. Production yields reached 95%. It was established that all the alkyl chains were included within the cyclodextrins' cavities in these nanoassemblies. The multivalent character of the interactions between the two polymers ensures the stability of the nanoassemblies. Moreover, empty cyclodextrin units remained accessible for the inclusion of compounds of interest such as benzophenon or tamoxifen. (c) 2006 Elsevier B.V. All rights reserved.
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