期刊
JOURNAL OF CELL BIOLOGY
卷 173, 期 1, 页码 59-68出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200509036
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资金
- NEI NIH HHS [P30 EY012190, EY12190, EY07361, R01 EY010609, EY10609, R01 EY007361, R56 EY010609] Funding Source: Medline
It is commonly assumed that photoreceptor (PR) outer segment (OS) morphogenesis is reliant upon the presence of peripherin/rds, hereafter termed Rds. In this study, we demonstrate a differential requirement of Rds during rod and cone OS morphogenesis. In the absence of this PR-specific protein, rods do not form OSs and enter apoptosis, whereas cone PRs develop atypical OSs and are viable. Such OSs consist of dysmorphic membranous structures devoid of lamellae. These tubular OSs lack any stacked lamellae and have reduced phototransduction efficiency. The loss of Rds only appears to affect the shape of the OS, as the inner segment and connecting cilium remain intact. Furthermore, these structures fail to associate with the specialized extracellular matrix that surrounds cones, suggesting that Rds itself or normal OS formation is required for this interaction. This study provides novel insight into the distinct role of Rds in the OS development of rods and cones.
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