期刊
NEUROLOGY
卷 66, 期 7, 页码 1100-1102出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/01.wnl.0000204179.88955.fa
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资金
- NIA NIH HHS [U01 AG06786, P50 AG16754] Funding Source: Medline
- NINDS NIH HHS [P50 NS40256] Funding Source: Medline
The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age ( N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.
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