期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 8, 页码 2189-2194出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.047
关键词
excitatory amino acid receptors; KA receptor agonist; KA reeptor antagonist; NMDA receptor agonist; dysiherbaine; scaffold
资金
- NIGMS NIH HHS [GM07311] Funding Source: Medline
- NINDS NIH HHS [R01 NS027600, NS-27600] Funding Source: Medline
The design and synthesis of four 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate-containing natural products, including (-)-dysiherbaine, is described. Biological evaluation of these analogs shows that one is a KA receptor antagonist and another is an NMDA receptor agonist. (C) 2006 Elsevier Ltd. All rights reserved.
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