期刊
DEVELOPMENT
卷 133, 期 8, 页码 1433-1443出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02329
关键词
Fez; zinc finger; olfactory sensory neuron; olfactory bulb; axon guidance; mitral cell; interneuron; rostral migratory stream; mouse
Fez is a zinc-finger gene encoding a transcriptional repressor that is expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. To reveal its function, we generated Fez-deficient mice. The Fez-deficient mice showed several abnormalities in the olfactory system: ( 1) impaired axonal projection of the olfactory sensory neurons; ( 2) reduced size of the olfactory bulb; ( 3) abnormal layer formation in the olfactory bulb; and ( 4) aberrant rostral migration of the interneuron progenitors. Fez was not expressed in the projection neurons, interneurons or interneuron progenitors. Transgene-mediated expression of Fez in olfactory sensory neurons significantly rescued the abnormalities in olfactory axon projection and in the morphogenesis of the olfactory bulb in Fez-knockout mice. Thus, Fez is cell-autonomously required for the axon termination of olfactory sensory neurons, and Fez non-cell-autonomously controls layer formation and interneuron development in the olfactory bulb. These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb.
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