期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 8, 页码 2278-2282出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.026
关键词
strobilurins; (E)-alpha-(methoxyimino)-benzeneacetates; substituted 1,3,4-oxadiazoles; fungicides
Fifteen novel (E)-alpha-(methoxyimino)-benzeneacetate derivatives, the analogues of strobilurins, which contain two pharmacophoric substructures of (E)-methyl methoxyiminoacetate moiety and 1,3,4-oxadiazole ring were stereoselectively synthesized. It was first found that the coupling reaction could give stereoselectively the key intermediate (E) and (Z)-methyl 2-(hydroxyimino)-2-o-tolylacetate 2 with a ratio of 14:1. The preliminary bioassays indicated that all the compounds 1 showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola and Bipolaris mayclis, and all of the tested Compounds 1a-1o had more potent fungicidal activities against R. solani than Kresoxim-methyl. (C) 2006 Elsevier Ltd. All rights reserved.
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