期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 16, 期 8, 页码 2148-2153出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.01.071
关键词
compare analysis; tandem Michael-aldol cyclization; anticancer agents
A diastereoselective synthesis of diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones is described employing a tandem Michael-aldol addition as key step. The novel compounds exhibit antiproliferative activity in a panel of in vitro cultivated cancer cell lines. The bioinformatic tool COMPARE was able to discriminate between two closely related subgroups of the title compounds, namely 1,3- and 2,3-disubstituted derivatives. (C) 2006 Elsevier Ltd. All rights reserved.
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