Evaluation of anti-inflammatory and antioxidant activities of mixed-ligand Cu(II) complexes of then and its Schiff dibases with heterocyclic aldehydes and 2-amino-2-thiazoline

A new series of complexes of the type [Cu(dien)(2a-2tzn)Y-2] and [Cu(dienXX)(2a-2tzn)Y-2] has been tested for anti-inflammatory and antioxidant activity. The tested compounds inhibit significantly the carrageenin induced paw edema (36.4-55.8%) and present important scavenging activities. Although their interaction with the free stable radical DPPH is not high they proxide anions. Compound 7 is the most potent (55.8%) in the in vivo experiment. Lipophilicity-as R-M values and theoretically calculated log P values-has been determined. Ail attempt to correlate the biological results with their structural characteristics and physicochemical parameters has been done. (C) 2006 Elsevier Ltd. All rights reserved.