期刊
FEBS LETTERS
卷 580, 期 9, 页码 2301-2305出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2006.03.042
关键词
antisense RNA; ADARs; Alu repeats; RNA editing; human transcriptome
资金
- NCI NIH HHS [P01 CA072765, P01 CA072765-050002] Funding Source: Medline
- NHLBI NIH HHS [R01 HL070045, R01 HL070045-04] Funding Source: Medline
- NIGMS NIH HHS [R01 GM040536, R01 GM040536-16] Funding Source: Medline
One type of RNA editing converts adenosine residues to inosine in double-stranded regions. Recent transcriptome analysis has revealed that numerous Alu repeats, present within introns and untranslated regions of human transcripts, are subject to this A -> I RNA editing. Furthermore, it revealed global transcription of antisense RNAs. Here, we demonstrate that antisense RNAs are also edited extensively but only in their Alu repeat sequences, and editing does not extend to the surrounding sequence. Our findings imply that sense and antisense RNAs form two separate intramolecular double-stranded RNAs consisting of inversely oriented Alu repeats, but rarely form intermolecular duplexes. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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