期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 203, 期 4, 页码 805-808出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20060215
关键词
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资金
- NCI NIH HHS [R01 CA108609, R01CA108609] Funding Source: Medline
CD4(+) T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-transformed B cells susceptible to lysis by CD4(+) T cells. Thus, antiviral vaccines should aim to stimulate both helper and cytolytic CD4(+) T cells.
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