期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 203, 期 4, 页码 1045-1054出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20051954
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资金
- NIAID NIH HHS [AI27998, R01 AI027998, R37 AI027998, R01 AI039614, AI39614] Funding Source: Medline
We explored the relationship between the time of naive CD4(+) T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4(+) T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of the antigen-specific population present at the peak of clonal expansion. These late-arriving T cells divided less and more retained the central-memory marker CD62L than the T cells that resided in the draining lymph nodes at the time of antigen injection. The fewer cell divisions were related to competition with resident T cells that expanded earlier in the response and a reduction in the number of dendritic cells displaying peptide-major histocompatibility complex (MHC) II complexes at later times after antigen injection. The progeny of late-arriving T cells possessed the phenotype of central-memory cells, and proliferated more extensively during the secondary response than the progeny of the resident T cells. The results suggest that late arrival into lymph nodes and exposure to antigen-presenting cells displaying lower numbers of peptide-MHC II complexes in the presence of competing T cells ensures that some antigen-specific CD4(+) T cells divide less in the primary response and become central-memory cells.
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