期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 128, 期 15, 页码 5292-5299出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja060369+
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资金
- NIGMS NIH HHS [GM-29028] Funding Source: Medline
A convergent stereocontrolled total synthesis of (-)-kendomycin (1) has been achieved. The synthesis proceeds with a longest linear sequence of 21 steps, beginning with commercially available 2,4-dimethoxy-3-methylbenzaldehyde (12). Highlights of the synthesis include an effective Petasis-Ferrier union/rearrangement tactic to construct the sterically encumbered tetrahydropyran ring, a ring-closing metathesis to generate the C(4a-13-20a) macrocycle, an effective epoxidation/deoxygenation sequence to isomerize the C(13,14) olefin, and a biomimetic quinone-methide-lactol assembly to complete the synthesis.
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