期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 49, 期 8, 页码 2543-2548出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm060041r
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New synthetic Substituted hexahydropyridoindoles were studied for their radical scavenging ability in a system of an ethanolic solution of alpha,alpha'-diphenyl-beta-picrylhydrazyI and for their lipid peroxidation inhibitory properties in a suspension of unilamellar diolcoylphosphatidylcholine liposomes. The activities in both in vitro systems were correlated with several structural parameters. In the homogeneous system of alpha,alpha-diphenyl-beta-picrylhydrazyl, the SLIM of aromatic substitution constants (Sigma sigma(+)) and the hydration energy were shown to be effective predictors of the radical scavenging activity of the hexahydropyridoindole derivatives. Moreover, in the heterogeneous system comprising a model liposomal membrane, the overall antioxidant activity of the compounds was affected by their lipid-phase availability governed by the lipophilicity and basicity of the molecules.
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