期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 495, 期 6, 页码 658-667出版社
WILEY
DOI: 10.1002/cne.20902
关键词
retinopetal; centrifugal; bipolar; amacrine; primate; dopamine
资金
- NEI NIH HHS [R01 EY006472, R01 EY006472-16A1, EY06472, P30 EY010608-12, EY12610, EY10608, P30 EY010608, R01 EY011105, EY11105] Funding Source: Medline
Mammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy. In monkeys, puncta containing HR3 were found at the tips of ON-bipolar cell dendrites in cone pedicles and rod spherules, closer to the photoreceptors than the other neurotransmitter receptors. This is the first ultrastructural localization of any histamine receptor and the first direct evidence that HR3 is present on postsynaptic membranes in the central nervous system. In rat retinas, most HR1 were localized to dopaminergic amacrine cells. The differences in histamine receptor localization may reflect the differences in the activity patterns of the two species.
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